Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of ritonavir

Volume: 27, Issue: 5, Pages: 702 - 712
Published: Jul 1, 2019
Abstract
Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints. In this study, formulations LP1 and LP2 were obtained (RTV 100 mg/unit dose) using microcrystalline cellulose (carrier), Kollidon® CL-SF (coating and...
Paper Details
Title
Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of ritonavir
Published Date
Jul 1, 2019
Volume
27
Issue
5
Pages
702 - 712
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