Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease
Abstract
Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic disorder involving benign mass formation due to fibrosis and intense lymphoplasmacytosis; the chronic inflammation associated with the disease might also contribute to oncogenesis. Activation-induced cytidine deaminase (AID), normally expressed in germinal centre activated B-cells, is an enzyme that edits DNA/RNA and induces somatic hypermutation and Ig class switching. AID...
Paper Details
Title
Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease
Published Date
Jan 24, 2019
Journal
Volume
9
Issue
1
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