Solubility, solution thermodynamics and molecular interactions of osimertinib in some pharmaceutically useful solvents

A key factor in dosage form development is selection of a suitable solvent for the solubility of drugs. Solubility data of osimertinib (OSM) are scarce in the research literature. In current study, thermodynamic solubility of OSM in eight different pharmaceutically useful solvents namely, water, ethanol, propylene glycol (PG), ethyl acetate (EA), isopropyl myristate (IPM), dichloromethane (DCM), Transcutol-HP (THP), and polyethylene glycol-400...