DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries
Abstract
Coordinated changes of DNA (de)methylation, nucleosome positioning, and chromatin binding of the architectural protein CTCF play an important role for establishing cell-type-specific chromatin states during differentiation. To elucidate molecular mechanisms that link these processes, we studied the perturbed DNA modification landscape in mouse embryonic stem cells (ESCs) carrying a double knockout (DKO) of the Tet1 and Tet2 dioxygenases. These...
Paper Details
Title
DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries
Published Date
Apr 4, 2019
Journal
Volume
29
Issue
5
Pages
750 - 761
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