PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
Abstract
B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer genes remains challenging. Here, we describe PiggyBac transposon tools and mouse models for recessive screening and show their application to study clonal B-cell lymphomagenesis. In a genome-wide screen, we discover BCL genes related to diverse molecular processes, including signaling,...
Paper Details
Title
PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
Published Date
Mar 29, 2019
Journal
Volume
10
Issue
1
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