Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites
Abstract
Desmocollin‐2 (DSC2) is a desmosomal protein of the cadherin family. Desmosomes are multiprotein complexes, which are involved in cell adhesion of cardiomyocytes and of keratinocytes. The molecular structure of the complete extracellular domain (ECD) of DSC2 was recently described, revealing three disulfide bridges, four N ‐glycosylation sites, and four O ‐mannosylation sites. However, the functional relevance of these post‐translational...
Paper Details
Title
Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites
Published Date
Apr 3, 2019
Journal
Volume
9
Issue
5
Pages
996 - 1007
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