Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity
Abstract
Using single-cell transcriptional profiling we mapped the immune system of the naked mole-rat ( Heterocephalus glaber ), a small but long-lived and cancer-resistant subterranean rodent. Both splenic and circulating immune cells were examined in healthy young animals and following an infection-mimicking lipopolysaccharide challenge. Our study revealed that the naked mole-rat immune system is characterized by a high myeloid to lymphoid cell ratio...
Paper Details
Title
Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity
Published Date
Apr 4, 2019
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