Survival after complete cytoreductive surgery and HIPEC for extensive pseudomyxoma peritonei

Published on Jun 1, 2019in Surgical Oncology-oxford3
· DOI :10.1016/j.suronc.2019.03.004
Leonor Benhaim2
Estimated H-index: 2
Matthieu Faron9
Estimated H-index: 9
+ 5 AuthorsDiane Goéré34
Estimated H-index: 34
Abstract Introduction The optimal treatment for pseudomyxoma peritonei (PMP) combines complete cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). Yet, achieving CRS is challenging in the case of extensive involvement of the peritoneal cavity and the survival benefit in this setting remains uncertain. The present study evaluated the surgical outcomes according to the peritoneal extent. Methods Between 1992 and 2014, 245 patients underwent CRS and HIPEC for PMP in our institution. Their characteristics were reviewed using a prospective database. Extensive PMP was defined as a peritoneal cancer index (PCI) ≥ 28. Sixty-one patients with extensive PMP were compared to 184 with non-extensive PMP. Results Severe complications were more frequent in the extensive group (46% vs. 23%, p  Conclusion CRS with HIPEC offers prolonged survival even in the case of extensive PMP. Because of the high rate of surgical morbidity in the extensive group, patients should be carefully selected.
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