A self-assembling collagen mimetic peptide system to simultaneously characterize the effects of osteogenesis imperfecta mutations on conformation, assembly and activity
Abstract
Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder occurring mainly due to missense mutations in collagen, which has complicated effects on stability and conformation of monomer collagen as well as the morphology and bioactivity of aggregated collagen. We have created a self-assembling collagen mimetic peptide system that for the first time facilitates simultaneous characterization of the effects of osteogenesis imperfecta...
Paper Details
Title
A self-assembling collagen mimetic peptide system to simultaneously characterize the effects of osteogenesis imperfecta mutations on conformation, assembly and activity
Published Date
May 22, 2019
Volume
7
Issue
20
Pages
3201 - 3209
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