Modern clinical Mtb strains leverage the type I IFN pathway for a pro-inflammatory response in the host
Abstract
null Host phagocytes are adept at responding to infections by innate immune mechanisms and metabolic alterations designed to restrict the invading pathogen. However, this very plasticity of the response provides an ideal platform for pathogen mediated manipulation. Clinical lineages of Mycobacterium tuberculosis have evolved distinct and numerous ways of achieving optimal infection. We demonstrate an early, active and prominent induction of the...
Paper Details
Title
Modern clinical Mtb strains leverage the type I IFN pathway for a pro-inflammatory response in the host
Published Date
Mar 31, 2019
Journal
Pages
594655
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History