Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis

To identify prediagnostic plasma metabolomic biomarkers associated with amyotrophic lateral sclerosis (ALS).We conducted a global metabolomic study using a nested case-control study design within 5 prospective cohorts and identified 275 individuals who developed ALS during follow-up. We profiled plasma metabolites using liquid chromatography-mass spectrometry and identified 404 known metabolites. We used conditional logistic regression to...