Structural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents.

Published on Apr 3, 2019in Psychophysiology3.378
· DOI :10.1111/PSYP.13376
Lauren Delaparte4
Estimated H-index: 4
(SBU: Stony Brook University),
Elizabeth Bartlett3
Estimated H-index: 3
(SBU: Stony Brook University)
+ 5 AuthorsRoman Kotov41
Estimated H-index: 41
(SBU: Stony Brook University)
: The five-factor model consists of cognitive-affective-behavioral trait dimensions (neuroticism, extraversion, openness to experience, agreeableness, conscientiousness) that are central to models of psychopathology. In adults, individual differences in three of the Big Five traits, neuroticism, extraversion, and conscientiousness, have been linked to structural morphology and connectivity of the orbitofrontal cortex (OFC) and the amygdala, two brain regions critically involved in affective and regulatory processing. It is unclear whether these associations manifest in adolescence, a critical neurodevelopmental period during which many forms of psychiatric illness emerge. A total of 223 adolescent girls (ages 14-16 years) completed a multimodal neuroimaging study that utilized T1-weighted structural MRI (e.g., cortical thickness and volume) and tractography-based diffusion tensor imaging (64-direction). Cortical thickness and volume were extracted from the medial orbitofrontal cortex (mOFC) and amygdala and tractography-based fractional anisotropy was computed in the uncinate fasciculus (UF; the white matter tract connecting the OFC to the temporal lobe). We found that high neuroticism was associated with less mOFC volume (bilateral), and low conscientiousness was associated with higher white matter integrity in the UF, more amygdala volume, and less mOFC thickness (right hemisphere). Extraversion was not observed to share associations with OFC markers. These OFC-amygdala structural correlations to personality do not match those reported in adult samples. Multimodal neuroimaging techniques can help to clarify the underpinnings of personality development between adolescence and adulthood.
  • References (63)
  • Citations (2)
📖 Papers frequently viewed together
82 Citations
3 Authors (Carl E. Fulwiler, ..., Zhang Nanyin)
43 Citations
2 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Mark S. Allen (UOW: University of Wollongong)H-Index: 19
#2Emma E. Walter (UOW: University of Wollongong)H-Index: 8
This meta-analytic review addresses whether the major dimensions of trait personality relate to components of human sexuality. A comprehensive literature search identified 137 studies that met inclusion criteria (761 effect sizes; total n = 420,595). Pooled mean effects were computed using inverse-variance weighted random effects meta-analysis. Mean effect sizes from 100 separate meta-analyses provided evidence that personality relates to theoretically predicted components of sexuality and sexua...
21 CitationsSource
#1Jingwen Jin (SBU: Stony Brook University)H-Index: 6
#2Ananth Narayanan (SBU: Stony Brook University)H-Index: 1
Last. Aprajita Mohanty (SBU: Stony Brook University)H-Index: 21
view all 9 authors...
Abstract Background Major depressive disorder is a leading cause of disability worldwide; however, little is known about pathological mechanisms involved in its development. Research in adolescent depression has focused on reward sensitivity and striatal mechanisms implementing it. The contribution of loss sensitivity to future depression, as well as the orbitofrontal cortex (OFC) mechanisms critical for processing losses and rewards, remains unexplored. Furthermore, it is unclear whether OFC fu...
13 CitationsSource
#1Jesús Privado (Complutense University of Madrid)H-Index: 9
#2Francisco J. Román (UAM: Autonomous University of Madrid)H-Index: 16
Last. Roberto Colom Marañón (UAM: Autonomous University of Madrid)H-Index: 1
view all 5 authors...
Abstract Personality neuroscience defines the scientific study of the neurobiological basis of personality. This field assumes that individual differences in personality traits are related with structural and functional variations of the human brain. Gray and white matters are structural properties considered separately in previous research. Available findings in this regard are largely disparate. Here we analyze the relationships between gray matter (cortical thickness (CT), cortical surface ar...
16 CitationsSource
#1Rachael G. Grazioplene (UMN: University of Minnesota)H-Index: 11
#2Robert S. Chavez (OSU: Ohio State University)H-Index: 13
Last. Colin G. DeYoung (UMN: University of Minnesota)H-Index: 41
view all 4 authors...
: The link between diagnoses of psychotic disorders and attenuated white matter connectivity is well established, but little is known about the degree to which similar white matter differences predict traits linked to psychosis-proneness in the general population. Moreover, intelligence is too rarely considered as a covariate in neural endophenotype studies, despite its known protective role against psychopathology in general and its associations with broad aspects of neural structure and functi...
12 CitationsSource
#1Angelina R. Sutin (FSU: Florida State University)H-Index: 43
#2Yannick Stephan (University of Montpellier)H-Index: 23
Last. Antonio Terracciano (FSU: Florida State University)H-Index: 55
view all 6 authors...
Abstract A sedentary lifestyle is harmful for health; personality traits may contribute to physical (in)activity. With participant-level data from 16 samples ( N > 125,000), we examined the personality correlates of physical inactivity, frequency of physical activity, and sedentary behavior (in a subset of samples). Lower Neuroticism and higher Conscientiousness were associated with more physical activity and less inactivity and sedentary behavior. Extraversion and Openness were also associated ...
69 CitationsSource
#1Alessandra D. Nostro (HHU: University of Düsseldorf)H-Index: 3
#2Veronika I. Müller (HHU: University of Düsseldorf)H-Index: 17
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 92
view all 4 authors...
Previous studies have shown that males and females differ in personality and gender differences have also been reported in brain structure. However, effects of gender on this "personality-brain" relationship are yet unknown. We therefore investigated if the neural correlates of personality differ between males and females. Whole brain voxel-based morphometry was used to investigate the influence of gender on associations between NEO FFI personality traits and gray matter volume (GMV) in a matche...
35 CitationsSource
#1Luciana Monteiro Moura (UNIFESP: Federal University of São Paulo)H-Index: 9
#2Matthew J. Kempton ('KCL': King's College London)H-Index: 34
Last. Andrea Parolin Jackowski (UNIFESP: Federal University of São Paulo)H-Index: 29
view all 17 authors...
Abstract In the last decade, several studies have described the typical brain white matter maturation in children and adolescents. Diffusion tensor imaging (DTI) is the most frequent MRI technique used to investigate the structural changes across development. However, few previous studies have used the magnetization transfer ratio (MTR), which gives a closer measure of myelin content. Here, we employed both techniques for the same sample of 176 typically developing children from 7 to 14 years of...
12 CitationsSource
#1Gary J. Lewis (RHUL: Royal Holloway, University of London)H-Index: 17
#2Simon R. Cox (Edin.: University of Edinburgh)H-Index: 22
Last. Ian J. Deary (Edin.: University of Edinburgh)H-Index: 133
view all 9 authors...
Establishing the neural bases of individual differences in personality has been an enduring topic of interest. However, while a growing literature has sought to characterize grey matter correlates of personality traits, little attention to date has been focused on regional white matter correlates of personality, especially for the personality traits agreeableness, conscientiousness and openness. To rectify this gap in knowledge we used a large sample (n > 550) of older adults who provided data o...
8 CitationsSource
#1Zafer Iscan (HSE: National Research University – Higher School of Economics)H-Index: 9
#2Tony B. Jin (SBU: Stony Brook University)H-Index: 4
Last. Christine DeLorenzo (SBU: Stony Brook University)H-Index: 16
view all 20 authors...
In the last decade, many studies have used automated processes to analyze magnetic resonance imaging (MRI) data such as cortical thickness, which is one indicator of neuronal health. Due to the convenience of image processing software (e.g., FreeSurfer), standard practice is to rely on automated results without performing visual inspection of intermediate processing. In this work, structural MRIs of 40 healthy controls who were scanned twice were used to determine the test–retest reliability of ...
66 CitationsSource
#1Zafer IscanH-Index: 9
#2Tony B. JinH-Index: 4
Last. Christine DeLorenzoH-Index: 16
view all 20 authors...
51 CitationsSource
Cited By2
#1Amirhossein Modabbernia (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 25
#3Abraham Reichenberg (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 58
Last. Andreas Becker (GAU: University of Göttingen)H-Index: 23
view all 36 authors...
Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available...
#1Peter J. Castagna (LSU: Louisiana State University)H-Index: 3
Trait neuroticism refers to individual differences in negative emotional response to threat, frustration, or loss, operationally defined by elevated levels of irritability, anger, sadness, anxiety, worry, hostility, self-consciousness, and vulnerability to mental and physical difficulties. While functional studies have been fairly consistent when identifying regions associated with neuroticism during emotional stimuli, structural imagining studies do not tend to find a relationship between amygd...
1 CitationsSource