Novel Genetic Locus of Visceral Fat and Systemic Inflammation

Context Visceral fat (VF), more than fat elsewhere in the body [mostly subcutaneous fat (SF)], promotes systemic inflammation and related disease. The mechanisms of preferentially visceral accumulation of body fat are largely unknown. Objective To identify genetic loci and mechanistic pathways of preferential accumulation of VF and associated low-grade systemic inflammation. Design Genome-wide association study (GWAS). Setting and Participants...