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Trial watch: Dietary interventions for cancer therapy

Published on Jul 3, 2019in OncoImmunology 5.50
· DOI :10.1080/2162402X.2019.1591878
Sarah Levesque4
Estimated H-index: 4
,
Jonathan Pol14
Estimated H-index: 14
+ 3 AuthorsGuido Kroemer191
Estimated H-index: 191
(UPMC: Pierre-and-Marie-Curie University)
Abstract
ABSTRACTDietary interventions have a profound impact on whole body metabolism, including oncometabolism (the metabolic features allowing cancer cells to proliferate) and immunometabolism (the catabolic and anabolic reactions that regulate immune responses). Recent preclinical studies demonstrated that multiple dietary changes can improve anticancer immunosurveillance of chemo-, radio- and immunotherapy. These findings have fostered the design of clinical trials evaluating the capacity of dietary interventions to synergize with treatment and hence limit tumor progression. Here, we discuss the scientific rationale for harnessing dietary interventions to improve the efficacy of anticancer therapy and present up-to-date information on clinical trials currently investigating this possibility.
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Published on Jan 11, 2019in Science 41.06
Andrew Wang12
Estimated H-index: 12
(Yale University),
Harding H. Luan6
Estimated H-index: 6
(Yale University),
Ruslan Medzhitov100
Estimated H-index: 100
(Yale University)
BACKGROUND Metabolism can be broadly divided into anabolic, energy-consuming, biosynthetic processes and energy-generating catabolic processes. Different biological functions rely on primarily catabolic or primarily anabolic metabolism. The field of immunometabolism has advanced our understanding of how allocation of metabolic resources (energy and metabolites) supports host defenses. On cellular, tissue, and organismal levels, emerging evidence demonstrates a complex interplay between metabolis...
6 Citations Source Cite
Published on Jan 2, 2019in OncoImmunology 5.50
Katsunobu Hagihara1
Estimated H-index: 1
(UCSF: University of California, San Francisco),
Stephen Y. Chan9
Estimated H-index: 9
(UCSF: University of California, San Francisco)
+ 4 AuthorsLawrence Fong39
Estimated H-index: 39
(UCSF: University of California, San Francisco)
ABSTRACTSipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood. We have previously shown that this treatment can induce the recruitment of CD4 and CD8 T cells to the tumor microenvironment. In this study, we examined the functional state of these T cells through gene expression profiling. We found that the magnitude of T cell signatures correlated with the frequency o...
1 Citations Source Cite
Published on Jan 1, 2019in Nature Medicine 32.62
Ziming Wang1
Estimated H-index: 1
(UC Davis: University of California, Davis),
Ethan G. Aguilar6
Estimated H-index: 6
(UC Davis: University of California, Davis)
+ 30 AuthorsIan R. Sturgill2
Estimated H-index: 2
(UC Davis: University of California, Davis)
The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imperative to identify factors impacting outcome. Obesity is reaching pandemic proportions and is a major risk factor for certain malignancies, but the impact of obesity on immune responses, in general and in cancer immunotherapy, is poorly understood. Here, we demonstrate, across multiple species and tumor models, that obesity resu...
11 Citations Source Cite
Published on Jan 1, 2019in Nature Reviews Cardiology 15.16
Massimo Bonora33
Estimated H-index: 33
(Albert Einstein College of Medicine),
Mariusz R. Wieckowski35
Estimated H-index: 35
(Nencki Institute of Experimental Biology)
+ 3 AuthorsLorenzo Galluzzi88
Estimated H-index: 88
(Paris V: Paris Descartes University)
A large body of evidence indicates that mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary efforts have been focused on the development of agents that specifically target mitochondria for the treatment of cardiovascular disease. Despite such an intensive wave of investigation, no drugs specifically conceived to modulate mitochondrial functions are currently available for the clinical management of cardiovasc...
8 Citations Source Cite
Published on Dec 15, 2018in Clinical Cancer Research 10.20
Ashley Orillion7
Estimated H-index: 7
(IUPUI: Indiana University – Purdue University Indianapolis),
Nur P. Damayanti6
Estimated H-index: 6
(IUPUI: Indiana University – Purdue University Indianapolis)
+ 13 AuthorsChinghai Kao2
Estimated H-index: 2
(IUPUI: Indiana University – Purdue University Indianapolis)
Purpose: Diet and healthy weight are established means of reducing cancer incidence and mortality. However, the impact of diet modifications on the tumor microenvironment and antitumor immunity is not well defined. Immunosuppressive tumor-associated macrophages (TAMs) are associated with poor clinical outcomes and are potentially modifiable through dietary interventions. We tested the hypothesis that dietary protein restriction modifies macrophage function toward antitumor phenotypes. Experiment...
3 Citations Source Cite
Published on Nov 28, 2018in Nature Reviews Drug Discovery 50.17
Jun Tang3
Estimated H-index: 3
,
Jia Xin Yu1
Estimated H-index: 1
+ 3 AuthorsYunqing Lin1
Estimated H-index: 1
10 Citations Source Cite
Published on Dec 1, 2018in BMC Cancer 3.29
Stephan P. Bauersfeld1
Estimated H-index: 1
(Humboldt University of Berlin),
Christian Kessler10
Estimated H-index: 10
(Humboldt University of Berlin)
+ 7 AuthorsAndreas Michalsen35
Estimated H-index: 35
(Humboldt University of Berlin)
This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n = 18) or vice versa (group B;n = 16). Fasting started 36 h ...
5 Citations Source Cite
Published on Dec 1, 2018in Journal of Translational Medicine 4.20
Laura Soldati22
Estimated H-index: 22
(University of Milan),
Laura Di Renzo19
Estimated H-index: 19
(University of Rome Tor Vergata)
+ 3 AuthorsAntonino De Lorenzo28
Estimated H-index: 28
(University of Rome Tor Vergata)
Immunotherapy has matured into standard treatment for several cancers, but much remains to be done to extend the reach of its effectiveness particularly to cancers that are resistant within each indication. This review proposes that nutrition can affect and potentially enhance the immune response against cancer. The general mechanisms that link nutritional principles to immune function and may influence the effectiveness of anticancer immunotherapy are examined. This represents also the premise ...
4 Citations Source Cite
Published on Nov 2, 2018in OncoImmunology 5.50
Shakila Jabeen2
Estimated H-index: 2
(University of Oslo),
Manuela Zucknick7
Estimated H-index: 7
(University of Oslo)
+ 12 AuthorsJon Amund Kyte4
Estimated H-index: 4
(Oslo University Hospital)
ABSTRACTA high concentration of circulating vascular endothelial growth factor (VEGF) in cancer patients is associated with an aggressive tumor phenotype. Here, serum levels of 27 cytokines and blood cell counts were assessed in breast cancer patients receiving neoadjuvant chemotherapy with or without bevacizumab (Bev) in a randomized cohort of 132 patients with non-metastatic HER2-negative tumors. Cytokine levels were determined prior to treatment and at various time-points. The cytotoxic chemo...
2 Citations Source Cite
Published on Oct 3, 2018in OncoImmunology 5.50
Gautier Stoll12
Estimated H-index: 12
,
Jonathan Pol14
Estimated H-index: 14
+ 2 AuthorsGuido Kroemer191
Estimated H-index: 191
(French Institute of Health and Medical Research)
ABSTRACTMultiple soluble factors including proteins (in particular chemokines), non-proteinaceous factors released by dead cells, as well as receptors for such factors (in particular chemokine receptors, formyl peptide receptors and purinergic receptors), influence the recruitment of distinct cell subsets into the tumor microenvironment. We performed an extensive bioinformatic analysis on tumor specimens from 5953 cancer patients to correlate the mRNA expression levels of chemotactic factors/rec...
4 Citations Source Cite
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