Adipose glucocorticoid action influences whole‐body metabolism via modulation of hepatic insulin action
Abstract
The connection between adipose glucocorticoid action and whole-body metabolism is incompletely understood. Thus, we generated adipose tissue-specific glucocorticoid receptor-knockout (Ad-GcR-/-) mice to explore potential mechanisms. Ad-GcR-/- mice had a lower concentration of fasting plasma nonesterified fatty acids and less hepatic steatosis. This was associated with increased protein kinase B phosphorylation and increased hepatic glycogen...
Paper Details
Title
Adipose glucocorticoid action influences whole‐body metabolism via modulation of hepatic insulin action
Published Date
Apr 28, 2019
Journal
Volume
33
Issue
7
Pages
8174 - 8185
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