Grape Seed Extract and Vitamin C Combination Blocked LPS-Induced Multiple Organ Toxicity in Mice

Gram-negative bacteria mediate multiple organ damage through eliciting systemic inflammatory response and extensive oxidative stress in affected humans and animals. This study was done to evaluatethe effect of grape seed extract (GSE) given alone or in combination with vitamin C (Vit C) on organ toxicity in mice treated with lipopolysaccharide (LPS). Mice received intraperitoneal injections of LPS on day 1 (4 mg/kg) and day 8 (2 mg/kg) of the...