The TMEM106B rs1990621 protective variant is also associated with increased neuronal proportion

Pages: 583286
Published: Mar 20, 2019
Abstract
Background: In previous studies, we observed decreased neuronal and increased astrocyte proportions in AD cases in parietal brain cortex by using a deconvolution method for bulk RNA-seq. These findings suggested that genetic risk factors associated with AD etiology have a specific effect in the cellular composition of AD brains. The goal of this study is to investigate if there are genetic determinants for brain cell compositions. Methods: Using...
Paper Details
Title
The TMEM106B rs1990621 protective variant is also associated with increased neuronal proportion
Published Date
Mar 20, 2019
Journal
Pages
583286
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