New insights emerge as antibody repertoire diversification meets chromosome conformation

Amy L. Kenter; Ann J. Feeney

doi:https://doi.org/10.12688/f1000research.17358.1

doi.org/10.12688/f1000research.17358.1

New insights emerge as antibody repertoire diversification meets chromosome conformation

,

Volume: 8, Pages: 347 - 347

Published: Mar 28, 2019

Abstract

Vast repertoires of unique antigen receptors are created in developing lymphocytes. The antigen receptor loci contain many variable (V), diversity (D), and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons. This process creates the potential for an organism to respond to large numbers of different pathogens. Here, we consider the underlying molecular mechanisms that...

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Paper Details

Title

New insights emerge as antibody repertoire diversification meets chromosome conformation

DOI

doi.org/10.12688/f1000research.17358.1

Published Date

Mar 28, 2019

Journal

F1000Research

Volume

8

Pages

347 - 347

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