Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in asthma is uncertain.Objectives: To characterize the role of activated neutrophils in severe asthma through measurement of NETs and inflammasome activation.Methods: We...