Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery
Abstract
The great therapeutic potential of peptides has not yet been achieved, mainly due to their remarkably short in vivo half-life. Although conjugation to macromolecules has been an effective way of improving protein in vivo half-life, the steric hindrance of macromolecules usually reduces the in vivo efficacy of peptides. Here we report a complex delivery system made from PsTag polypeptide, polyglutamic acid chain, matrix metalloproteinase 2...
Paper Details
Title
Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery
Published Date
Jun 1, 2019
Journal
Volume
452
Pages
38 - 50
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Notes
History