Adipose Mitochondrial Respiratory Capacity in Obesity is Impaired Independently of Glycemic Status of Tissue Donors

Objective The study aimed to investigate how obesity and glycemic state affect mitochondrial respiration and ATP–generating pathways in mature human adipocytes. Methods Subcutaneous (sc) and visceral (vc) adipocytes were isolated from patients undergoing abdominal surgery. Respiratory chain function was analyzed by high‐resolution respirometry. Adipocyte ATP levels and lactate release were measured separately in the presence of either glycolysis...