(275) Somatosensory Predictors of Response to Pregabalin in Painful Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Randomized, Placebo-Controlled, Crossover Study

Painful chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and treatment-resistant sequela of many chemotherapeutic medications. Ligands of α2δ subunits of voltage-gated Ca2+ channels, such as pregabalin, have shown efficacy in reducing mechanical hypersensitivity in animal models of neuropathic pain. In addition, some data suggested that pregabalin may be more efficacious in relieving neuropathic pain in subjects with increased...