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Perioperative Care for Lung Transplant Recipients: A Multidisciplinary Approach

Published on Mar 21, 2019
路 DOI :10.5772/intechopen.85277
Stacey Brann1
Estimated H-index: 1
,
Steven S. Geier2
Estimated H-index: 2
+ 3 AuthorsYoshiya Toyoda36
Estimated H-index: 36
Abstract
  • References (31)
  • Citations (0)
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References31
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#1G. SunagawaH-Index: 1
#2Norihisa ShigemuraH-Index: 25
Last. Yoshiya ToyodaH-Index: 36
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#1Anat R. Tambur (NU: Northwestern University)H-Index: 25
#2Patricia Campbell (U of A: University of Alberta)H-Index: 21
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#1Dirk Vanraemdonck (Katholieke Universiteit Leuven)H-Index: 55
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BackgroundSingle antigen beads (SAB) are used for monitoring HLA antibodies in pretransplant and posttransplant patients despite the discrepancy between virtual and actual crossmatch results and transplant outcomes. This discrepancy can be attributed to the presence of conformational variants of HLA
8 CitationsSource
#1Hrishikesh S. Kulkarni (WashU: Washington University in St. Louis)H-Index: 10
#2Bradford C. Bemiss (WashU: Washington University in St. Louis)H-Index: 1
Last. Ramsey Hachem (WashU: Washington University in St. Louis)H-Index: 28
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There has been increasing awareness of antibody-mediated rejection (AMR) as an important cause of graft failure after lung transplantation in recent years. However, the diagnostic criteria for pulmonary AMR are not well defined. All four tenets of AMR in kidney and heart transplantation, graft dysfunction, complement component deposition, circulating donor-specific antibodies (DSA), and histopathologic changes consistent with AMR are infrequently present in lung transplantation. Nonetheless, the...
11 CitationsSource
#1Jonathan Visentin (University of Bordeaux)H-Index: 10
Last. Jean-Luc Taupin (University of Bordeaux)H-Index: 29
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Anti-HLA donor-specific antibodies are deleterious for organ transplant survival. Class I HLA donor-specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti-denatured HLA antibodies (anti-dHLAs). Anti-dHLAs are thought to be unable to recognize native HLA (nHLA) on the cell surface and therefore to be clinically irrelevant. Acid denaturation of nHLA on LSAB allows anti-dHLAs to be discriminated from anti-nHLAs. We previously defined a thr...
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