Match!

Perioperative Care for Lung Transplant Recipients: A Multidisciplinary Approach

Published on Mar 21, 2019
· DOI :10.5772/INTECHOPEN.85277
Stacey Brann1
Estimated H-index: 1
,
Steven S. Geier3
Estimated H-index: 3
+ 3 AuthorsYoshiya Toyoda16
Estimated H-index: 16
Abstract
  • References (31)
  • Citations (0)
📖 Papers frequently viewed together
2019
1 Author (Alexander Vitin)
78% of Scinapse members use related papers. After signing in, all features are FREE.
References31
Newest
: This article reviews the current evidence to classify donor-specific antibodies (DSAs) using Food and Drug Administration-National Institutes of Health Biomarkers, EndpointS, and other Tools (BEST) resource terms as diagnostic, prognostic, predictive, monitoring, and risk biomarkers for graft rejection. The emphasis is on DSA characteristics, including the DSA levels determined by mean fluorescence intensity and/or titers, the ability to activate a complement cascade (C1q, C3d, and C4d binding...
1 CitationsSource
#1G. SunagawaH-Index: 1
#2Norihisa ShigemuraH-Index: 24
Last. Yoshiya ToyodaH-Index: 16
view all 6 authors...
1 CitationsSource
#1Anat R. Tambur (NU: Northwestern University)H-Index: 25
#2Patricia Campbell (U of A: University of Alberta)H-Index: 22
Last. Peter Nickerson (UM: University of Manitoba)H-Index: 50
view all 42 authors...
: The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced significantly in recent years, the criteria to define presence of a DSA and assign a level of risk for a given DSA vary markedly between centers. A collaborative effort between the American Society for Histocompatibility and Immunogenetics and t...
28 CitationsSource
1 CitationsSource
#1Andrew M. Courtwright (HUP: Hospital of the University of Pennsylvania)H-Index: 12
#2Joshua M. Diamond (HUP: Hospital of the University of Pennsylvania)H-Index: 25
Last. Hilary J. Goldberg (Brigham and Women's Hospital)H-Index: 18
view all 7 authors...
: There is significant variability in lung transplant centers' approach to HLA antibodies, creating heterogeneity regarding their clinical significance. Some institutions use beads coated with multiple HLA to screen candidate sera and then use single antigen bead (SAB) to determine antibody identity if the pre-screen is positive. Other centers do not pre-screen, using SAB alone, which may detect low-level antibodies of unknown significance. The primary objective of this study was to review the c...
4 CitationsSource
#1Andrew E. Gelman (WashU: Washington University in St. Louis)H-Index: 33
#2Andrew J. Fisher (Newcastle University)H-Index: 35
Last. Micheal S. Mulligan (UW: University of Washington)H-Index: 1
view all 7 authors...
34 CitationsSource
#1Dirk Vanraemdonck (Katholieke Universiteit Leuven)H-Index: 56
#2Matthew G. Hartwig (Duke University)H-Index: 27
Last. Shaf Keshavjee (U of T: University of Toronto)H-Index: 76
view all 17 authors...
15 CitationsSource
#1Vadim JucaudH-Index: 8
Last. Paul I. TerasakiH-Index: 93
view all 3 authors...
BackgroundSingle antigen beads (SAB) are used for monitoring HLA antibodies in pretransplant and posttransplant patients despite the discrepancy between virtual and actual crossmatch results and transplant outcomes. This discrepancy can be attributed to the presence of conformational variants of HLA
8 CitationsSource
#1Hrishikesh S. Kulkarni (WashU: Washington University in St. Louis)H-Index: 11
#2Bradford C. Bemiss (WashU: Washington University in St. Louis)H-Index: 1
Last. Ramsey R. Hachem (WashU: Washington University in St. Louis)H-Index: 31
view all 3 authors...
There has been increasing awareness of antibody-mediated rejection (AMR) as an important cause of graft failure after lung transplantation in recent years. However, the diagnostic criteria for pulmonary AMR are not well defined. All four tenets of AMR in kidney and heart transplantation, graft dysfunction, complement component deposition, circulating donor-specific antibodies (DSA), and histopathologic changes consistent with AMR are infrequently present in lung transplantation. Nonetheless, the...
11 CitationsSource
#1Jonathan Visentin (University of Bordeaux)H-Index: 12
Last. Jean-Luc Taupin (University of Bordeaux)H-Index: 29
view all 5 authors...
Anti-HLA donor-specific antibodies are deleterious for organ transplant survival. Class I HLA donor-specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti-denatured HLA antibodies (anti-dHLAs). Anti-dHLAs are thought to be unable to recognize native HLA (nHLA) on the cell surface and therefore to be clinically irrelevant. Acid denaturation of nHLA on LSAB allows anti-dHLAs to be discriminated from anti-nHLAs. We previously defined a thr...
24 CitationsSource
Cited By0
Newest