T cell stemness and dysfunction in tumors are triggered by a common mechanism
Abstract
A paradox of tumor immunology is that tumor-infiltrating lymphocytes are dysfunctional in situ, yet are capable of stem cell-like behavior including self-renewal, expansion, and multipotency, resulting in the eradication of large metastatic tumors. We find that the overabundance of potassium in the tumor microenvironment underlies this dichotomy, triggering suppression of T cell effector function while preserving stemness. High levels of...
Paper Details
Title
T cell stemness and dysfunction in tumors are triggered by a common mechanism
Published Date
Mar 29, 2019
Journal
Volume
363
Issue
6434
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