Design space determination and process optimization in at-scale continuous twin screw wet granulation

Volume: 125, Pages: 271 - 286
Published: Jun 1, 2019
Abstract
At-scale industrial continuous twin screw wet granulation process was analyzed and optimized via design of experiment (DoE). The Box-Behnken method was selected to investigate the influence of key process variables on granule properties and tablet properties. The effects of the key process variables were analyzed. The experimental results have demonstrated that both the granule properties and tablet properties are influenced by the throughput,...
Paper Details
Title
Design space determination and process optimization in at-scale continuous twin screw wet granulation
Published Date
Jun 1, 2019
Volume
125
Pages
271 - 286
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