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Statin Therapy Before Transition to End‐Stage Renal Disease With Posttransition Outcomes

Published on Mar 19, 2019in Journal of the American Heart Association4.66
· DOI :10.1161/JAHA.118.011869
Melissa Soohoo15
Estimated H-index: 15
(UCI: University of California, Irvine),
Hamid Moradi21
Estimated H-index: 21
(UCI: University of California, Irvine)
+ 8 AuthorsElani Streja36
Estimated H-index: 36
(UCI: University of California, Irvine)
Abstract
Background Although studies have shown that statin therapy in patients with non–dialysis‐dependent chronic kidney disease was associated with a lower risk of death, this was not observed in dialysi...
  • References (49)
  • Citations (1)
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References49
Newest
#1Melissa Soohoo (UCI: University of California, Irvine)H-Index: 15
#2Elani Streja (UCI: University of California, Irvine)H-Index: 36
Last. Kamyar Kalantar-Zadeh (UCI: University of California, Irvine)H-Index: 96
view all 9 authors...
Abstract Objective To determine whether kidney function level and its rate of decline in the immediate predialysis period among veterans transitioning to end-stage renal disease (ESRD) predict postdialysis mortality and hospitalization. Patients and Methods In 19,985 veterans transitioning to ESRD during the period October 1, 2007, to March 30, 2014, we examined kidney function and its slope over the final year of the pre-ESRD(prelude) period. Two categories of low vs high estimated glomerular f...
2 CitationsSource
#1Yoshitsugu ObiH-Index: 20
#2Christina ParkH-Index: 4
Last. Elani StrejaH-Index: 36
view all 9 authors...
Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. Although hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans who transitioned to dialysis in all US Department of Veterans Affairs health care facilities over 2009 to 2014 to examine the associations w...
3 CitationsSource
Author(s): Saran, Rajiv; Robinson, Bruce; Abbott, Kevin C; Agodoa, Lawrence YC; Bhave, Nicole; Bragg-Gresham, Jennifer; Balkrishnan, Rajesh; Dietrich, Xue; Eckard, Ashley; Eggers, Paul W; Gaipov, Abduzhappar; Gillen, Daniel; Gipson, Debbie; Hailpern, Susan M; Hall, Yoshio N; Han, Yun; He, Kevin; Herman, William; Heung, Michael; Hirth, Richard A; Hutton, David; Jacobsen, Steven J; Jin, Yan; Kalantar-Zadeh, Kamyar; Kapke, Alissa; Kovesdy, Csaba P; Lavallee, Danielle; Leslie, Janet; McCullough, Kei...
148 CitationsSource
#1Christina Reith (University of Oxford)H-Index: 14
#2Natalie Staplin (University of Oxford)H-Index: 12
Last. Martin J. Landray (University of Oxford)H-Index: 35
view all 14 authors...
Background Reducing LDL cholesterol (LDL-C) with statin-based therapy reduces the risk of major atherosclerotic events among patients with chronic kidney disease (CKD), with no evidence of an excess risk of cancer or death from any non-vascular cause. However, non-randomized data have suggested that statin therapy may have effects (both adverse and beneficial) on particular non-vascular conditions that do not cause death.
5 CitationsSource
#1Matthias J. Fischer (UIUC: University of Illinois at Urbana–Champaign)H-Index: 22
#2Kevin T. Stroupe (LUC: Loyola University Chicago)H-Index: 20
Last. Denise M. Hynes (UIC: University of Illinois at Chicago)H-Index: 26
view all 8 authors...
Background Predialysis nephrology care is associated with lower mortality and rates of hospitalization following chronic dialysis initiation. Whether more frequent predialysis nephrology care is associated with other favorable outcomes for older adults is not known.
21 CitationsSource
#1Rine Nakanishi (Los Angeles Biomedical Research Institute)H-Index: 15
#2Indre Ceponiene (Los Angeles Biomedical Research Institute)H-Index: 6
Last. Matthew J. Budoff (Los Angeles Biomedical Research Institute)H-Index: 99
view all 12 authors...
Abstract Background and aims We aimed at investigating whether diabetes is associated with progression in coronary plaque components. Methods We identified 142 study subjects undergoing serial coronary computed tomography angiography. The resulting propensity score was applied 1:1 to match diabetic patients to non-diabetic patients for clinical risk factors, prior coronary stenting, coronary artery calcium (CAC) score and the serial scan interval, resulting in the 71 diabetes and 71 non-diabetes...
15 CitationsSource
#1Yuzo WatanabeH-Index: 18
#2Tadao Akizawa (Showa University)H-Index: 39
Last. Yasuo Ohashi (Chu-Dai: Chuo University)H-Index: 19
view all 16 authors...
Progression of anemia in patients with chronic kidney disease (CKD) is associated with an increased risk of death and hospitalization. It is not sufficiently clear whether treating renal anemia with recombinant human erythropoietin (rHuEPO) has a beneficial effect on early survival after hemodialysis (HD) initiation in patients with CKD. The study was an open-label multicenter retrospective cohort study to evaluate the relationship between rHuEPO treatment and early survival after HD initiation ...
4 CitationsSource
#1Miklos Z. Molnar (UTHSC: University of Tennessee Health Science Center)H-Index: 48
#2Elvira O. Gosmanova (Albany Medical College)H-Index: 12
Last. Csaba P. Kovesdy (UTHSC: University of Tennessee Health Science Center)H-Index: 70
view all 12 authors...
Background Medication nonadherence is a known risk factor for adverse outcomes in the general population. However, little is known about the association of predialysis medication adherence among patients with advanced chronic kidney disease and mortality following their transition to dialysis. Study Design Observational study. Setting & Participants 32,348 US veterans who transitioned to dialysis during 2007 to 2011. Predictors Adherence to treatment with cardiovascular drugs, ascertained from p...
31 CitationsSource
#1Keith C. Norris (UCLA: University of California, Los Angeles)H-Index: 57
#2George A. Mensah (NIH: National Institutes of Health)H-Index: 85
Last. Csaba P. KovesdyH-Index: 70
view all 9 authors...
Background: In the general population, compared wtih their White peers, African Americans suffer premature all-cause and cardiovascular (CV) deaths, attributed in part to reduced access to care and lower socioeconomic status. Prior reports indicated younger (aged 35 to 44 years) African Americans had a signficantly greater age-adjusted risk of death. Recent studies suggest that in a more egalitarian health care structure than typical United States (US) health care structures, African Americans m...
3 CitationsSource
James L. Januzzi, Jr, MD, FACC, Chair Luis C. Afonso, MBBS, FACC Anthony Bavry, MD, FACC Brendan M. Everett, MD, FACC Jonathan Halperin, MD, FACC Adrian Hernandez, MD, FACC Hani Jneid, MD, FACC Dharam J. Kumbhani, MD, SM, FACC Eva M. Lonn, MD, FACC James K. Min, MD, FACC Pamela B. Morris
267 CitationsSource
Cited By1
Newest
#1Gunnar H. Heine (Saarland University)H-Index: 34
#2Kathrin Eller (Medical University of Graz)H-Index: 19
Last. Gunther Marsche (Medical University of Graz)H-Index: 32
view all 5 authors...
Abstract Chronic kidney disease (CKD), which affects >10% of the population worldwide, is associated with a dramatically increased rate of cardiovascular disease (CVD). More people with CKD will die from CVD than develop end-stage renal disease with dialysis-dependency. However, the contribution of classical atherosclerotic cardiovascular risk factors is less evident than in the general population. Particularly, the relationship between dyslipidemia and CVD morbidity and mortality in CKD patient...
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Abstract End-stage renal disease (ESRD) is a complex condition that requires knowledge and expertise for its effective management. Nurse practitioners continuously strive to provide adequate and safe care based on rigorous research. The objective of this article is to provide a structured and applicable approach to managing ESRD that is up-to-date and evidence based. To achieve this objective, we created an alphabetized mnemonic and synthesized our discussion to address Anemia, Bone health, Card...
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