Genetic Risk Variants Interacting With MIR137: Effects On Cognition, Brain Structure And Brain Function In Patients And Healthy Participants

Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, are associated with poorer cognitive performance. As microRNA-137 is known to regulate the expression of ~1900 other genes, including several that are independently associated with schizophrenia, we tested whether this gene set was also associated with variation in cognition, brain structure and brain function. Our analysis was...