Functional characterization of PALMD risk locus in calcific aortic valve stenosis

Calcific aortic valve stenosis (CAVS) is the most common heart valve disorder. Genome and transcriptome-wide association studies identified risk variant rs6702619 at the PALMD locus as casually associated with CAVS and with lower PALMD expression. To map and fine-grain molecular analyses to probe the regulation and function of PALMD. Regulation of the PALMD risk locus and its impact on valve interstitial cells (VICs) were evaluated. Reporter...