The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity

Volume: 374, Issue: 1772, Pages: 20180094 - 20180094
Published: Mar 25, 2019
Abstract
CRISPR-Cas immune systems are present in around half of bacterial genomes. Given the specificity and adaptability of this immune mechanism, it is perhaps surprising that they are not more widespread. Recent insights into the requirement for specific host factors for the function of some CRISPR-Cas subtypes, as well as the negative epistasis between CRISPR-Cas and other host genes, have shed light on potential reasons for the partial distribution...
Paper Details
Title
The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity
Published Date
Mar 25, 2019
Volume
374
Issue
1772
Pages
20180094 - 20180094
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