Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development

Volume: 6, Issue: 3, Pages: 480 - 493
Published: May 1, 2019
Abstract
Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys (8 first-generation and 3 second-generation) carrying human copies of MCPH1, an important gene for brain development and brain evolution. Brain-image and tissue-section analyses indicated an altered...
Paper Fields
Paper Details
Title
Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development
Published Date
May 1, 2019
Volume
6
Issue
3
Pages
480 - 493
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.