Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development
Abstract
Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys (8 first-generation and 3 second-generation) carrying human copies of MCPH1, an important gene for brain development and brain evolution. Brain-image and tissue-section analyses indicated an altered...
Paper Details
Title
Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development
Published Date
May 1, 2019
Journal
Volume
6
Issue
3
Pages
480 - 493
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