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Association of Life’s Simple 7 with reduced clinically manifest abdominal aortic aneurysm: The ARIC study

Published on Jun 1, 2019in Vascular Medicine2.158
· DOI :10.1177/1358863X19829226
Abayomi O. Oyenuga1
Estimated H-index: 1
(UMN: University of Minnesota),
Aaron R. Folsom159
Estimated H-index: 159
(UMN: University of Minnesota)
+ 1 AuthorsWeihong Tang32
Estimated H-index: 32
(UMN: University of Minnesota)
Abstract
To optimize cardiovascular health, the American Heart Association (AHA) has recommended ‘Life’s Simple 7 (LS7)’. We tested the hypothesis that greater adherence to the LS7 cardiovascular risk metric is associated with reduced risk of developing abdominal aortic aneurysm (AAA). A total of 14,375 black and white participants aged 45–64 years at the baseline visit of the Atherosclerosis Risk in Communities (ARIC) study cohort were included in this analysis. A 14-point summary score for LS7 was calculated, and participants were classified as having poor (0–4), average (5–9), or ideal (10–14) cardiovascular health. We also counted the number of ideal components. Poisson regression was used to calculate incidence rates for AAA, and Cox regression to calculate hazard ratios adjusted for age, race, sex, and socioeconomic status. Over 25 years of follow-up, we identified 545 clinically manifest AAA events. Incident rates per 1000 person-years declined markedly across LS7 categories: 3.4 for the ‘poor’ category, 2....
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References31
Newest
#1Yasuhiko Kubota (UMN: University of Minnesota)H-Index: 4
#2Aaron R. Folsom (UMN: University of Minnesota)H-Index: 159
Last. Weihong Tang (UMN: University of Minnesota)H-Index: 32
view all 5 authors...
Abstract Purpose To test the hypothesis that diabetes-related factors (metabolic syndrome [MetS], glucose, insulin, and leptin) are inversely associated with abdominal aortic aneurysm (AAA) risk. Methods We followed 13,736 participants, aged 45–64 years, without prior AAA surgery at baseline (1987–1989), for AAA occurrence through 2011. Hazard ratios (HRs) and their 95% confidence intervals (CIs) of AAA were calculated using Cox regression. Results During 275,054 person-years of follow-up, we id...
3 CitationsSource
#1Weihong TangH-Index: 32
#2Lu Yao (UMN: University of Minnesota)H-Index: 4
Last. Aaron R. FolsomH-Index: 159
view all 12 authors...
Objective—Abdominal aortic aneurysm (AAA) is an important vascular disease in older adults, but data on lifetime risk of AAA are sparse. We examined lifetime risk of AAA in a community-based cohort...
32 CitationsSource
#1Oluseye Ogunmoroti (FIU: Florida International University)H-Index: 9
#2Norrina B Allen (NU: Northwestern University)H-Index: 20
Last. Khurram Nasir (FIU: Florida International University)H-Index: 55
view all 11 authors...
Background The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We examined the association between the LS7 metrics and noncardiovascular disease. Methods and Results We studied 6506 men and women aged between 45 and 84 years, enrolled in the Multi‐Ethnic Study of Atherosclerosis. Median follow‐up time was 10.2 years. Each component of the LS7 metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood p...
17 CitationsSource
#1Aaron R. Folsom (UMN: University of Minnesota)H-Index: 159
#2Amil M. Shah (Brigham and Women's Hospital)H-Index: 44
Last. Scott D. Solomon (Brigham and Women's Hospital)H-Index: 107
view all 10 authors...
Abstract Background Many people may underappreciate the role of lifestyle in avoiding heart failure. We estimated whether greater adherence in middle age to American Heart Association's Life's Simple 7 guidelines—on smoking, body mass, physical activity, diet, cholesterol, blood pressure, and glucose—is associated with lower lifetime risk of heart failure and greater preservation of cardiac structure and function in old age. Methods We studied the population-based Atherosclerosis Risk in Communi...
61 CitationsSource
#1Aaron R. Folsom (UMN: University of Minnesota)H-Index: 159
#2Lu Yao (UMN: University of Minnesota)H-Index: 4
Last. Weihong Tang (UMN: University of Minnesota)H-Index: 32
view all 8 authors...
Background —The etiology of abdominal aortic aneurysm (AAA) is complex. Cross-sectional studies have connected circulating biomarkers with AAA, but prospective evidence is limited. Methods and Results —In the Atherosclerosis Risk in Communities Study cohort, we measured multiple blood biomarkers of inflammation, hemostasis, thrombin generation, cardiac dysfunction, and vascular stiffness and identified incident AAAs during follow-up using hospital discharge codes. Six biomarkers (white blood cel...
30 CitationsSource
#1Aaron R. Folsom (UMN: University of Minnesota)H-Index: 159
#2Nels C. Olson (UVM: University of Vermont)H-Index: 11
Last. M. Cushrnan (UVM: University of Vermont)H-Index: 108
view all 5 authors...
7 CitationsSource
#1Nels C. Olson (UVM: University of Vermont)H-Index: 11
#2M. Cushrnan (UVM: University of Vermont)H-Index: 108
Last. Neil A. Zakai (UVM: University of Vermont)H-Index: 31
view all 8 authors...
Background The American Heart Association's Life's Simple 7 metric is being used to track the population's cardiovascular health (CVH) toward a 2020 goal for improvement. The metric includes body mass index (BMI), blood pressure, cholesterol, glucose, physical activity (PA), cigarette smoking, and diet. We hypothesized a lower risk of venous thromboembolism (VTE) with favorable Life's Simple 7 scores. Methods and Results REGARDS recruited 30 239 black and white participants ≥45 years of age acro...
33 CitationsSource
#1T.M.M. Joergensen (University of Southern Denmark)H-Index: 3
#2Kim Christian Houlind (University of Southern Denmark)H-Index: 14
Last. Jes Sanddal Lindholt (OUH: Odense University Hospital)H-Index: 46
view all 4 authors...
Objective To investigate, at a population level, whether a family history of abdominal aortic aneurysm (AAA) is independently related to increased aortic diameter and prevalence of AAA in men, and to elucidate whether the mean aortic diameter and the prevalence of AAA are different between participants with male and female relatives with AAA. Design Observational population-based cross-sectional study. Materials 18,614 male participants screened for AAA in the VIVA-trial 2008–2011 with informati...
21 CitationsSource
DESCRIPTION: Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for abdominal aortic aneurysm (AAA). METHODS: The USPSTF commissioned a systematic review that assessed the evidence on the benefits and harms of screening for AAA and strategies for managing small (3.0 to 5.4 cm) screen-detected AAAs. POPULATION: These recommendations apply to asymptomatic adults aged 50 years or older. RECOMMENDATION: The USPSTF recommends 1-time screening for AAA with ultr...
134 CitationsSource
#1Holger Wemmelund (Aarhus University Hospital)H-Index: 4
#2Annette HøghH-Index: 6
Last. Jes Sanddal Lindholt (OUH: Odense University Hospital)H-Index: 46
view all 6 authors...
Background Ruptured abdominal aortic aneurysm (rAAA) is associated with high mortality. Research suggests that statins may reduce abdominal aortic aneurysm (AAA) growth and improve rAAA outcomes. However, the clinical impact of statins remains uncertain in relation to both the risk and prognosis of rAAA. Methods This nationwide, population-based, combined case–control and follow-up study included all patients (aged at least 50 years) with a first-time hospital admission for rAAA and 1 : 1 matche...
30 CitationsSource
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