CCL8 enhances sensitivity of cutaneous squamous cell carcinoma to photodynamic therapy by recruiting M1 macrophages

Antitumor immunity induced by photodynamic therapy (PDT) is believed to depend on the degree of local and systemic inflammation. The recruitment of leukocytes, in particular by the chemokine CCL8, to the sites of tissue damage has been strongly associated with the initiation of inflammatory reactions. To evaluate whether and how CCL8 enhances the immune response against tumors in 5-aminolevulinic acid (ALA)-mediated PDT. In this study, we...