Stratification of asthma phenotypes by airway proteomic signatures

Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our accuracy in prediction of treatment responses and a need for better understanding of the underlying mechanisms.We sought to identify molecular subphenotypes of asthma defined by proteomic signatures for improved stratification.Unbiased label-free quantitative mass spectrometry and topological...