Hoxa13regulates expression of commonHoxtarget genes involved in cartilage development to coordinate the expansion of the autopodal anlage

Volume: 61, Issue: 3, Pages: 228 - 251
Published: Mar 20, 2019
Abstract
To elucidate the role of Hox genes in limb cartilage development, we identified the target genes of HOXA11 and HOXA13 by ChIP-Seq. The ChIP DNA fragment contained evolutionarily conserved sequences and multiple highly conserved HOX binding sites. A substantial portion of the HOXA11 ChIP fragment overlapped with the HOXA13 ChIP fragment indicating that both factors share common targets. Deletion of the target regions neighboring Bmp2 or Tshz2...
Paper Details
Title
Hoxa13regulates expression of commonHoxtarget genes involved in cartilage development to coordinate the expansion of the autopodal anlage
Published Date
Mar 20, 2019
Volume
61
Issue
3
Pages
228 - 251
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