Abstract 115: AT2 Receptor Regulates Ascending Aortic Dilation during AT1 Receptor Blockade in Transverse Aortic Constriction Mouse Model

Introduction: The angiotensin II (Ang II) type 1 receptor (AT1R) antagonist losartan can slow aortic enlargement in mouse models and patients with Marfan syndrome. We have previously shown that losartan attenuates aortic enlargement and remodeling induced by thoracic aortic constriction (TAC). Objective: We investigated the role of the Ang II type 2 receptor (AT2R) in an acute hypertensive remodeling of the ascending aorta induced by TAC....