Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction
Abstract
A hallmark of cancer is genomic instability, which can enable cancer cells to evade therapeutic strategies. Here we employed a computational approach to uncover mechanisms underlying cancer mutational burden by focusing upon relationships between 1) translocation breakpoints and the thousands of G4 DNA-forming sequences within retrotransposons impacting transcription and exemplifying probable non-B DNA structures and 2) transcriptome profiling...
Paper Details
Title
Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction
Published Date
Oct 1, 2019
Volume
147
Pages
47 - 61
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