Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the integrated stress response (ISR). This is a key step in translational control and must be tightly regulated; however, persistent eIF2α phosphorylation is observed in mouse and human atheroma.Potent ISR inhibitors that modulate neurodegenerative disorders have been identified. Here, the...