Magnesium Flux Modulates Ribosomes to Increase Bacterial Survival
Abstract
Bacteria exhibit cell-to-cell variability in their resilience to stress, for example, following antibiotic exposure. Higher resilience is typically ascribed to "dormant" non-growing cellular states. Here, by measuring membrane potential dynamics of Bacillus subtilis cells, we show that actively growing bacteria can cope with ribosome-targeting antibiotics through an alternative mechanism based on ion flux modulation. Specifically, we observed...
Paper Details
Title
Magnesium Flux Modulates Ribosomes to Increase Bacterial Survival
Published Date
Apr 1, 2019
Journal
Volume
177
Issue
2
Pages
352 - 360.e13
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