Most unambiguous loss-of-function CPA1 mutations are unlikely to predispose to chronic pancreatitis

We have read with interest the recent publication of Hegyi and Sahin-Toth1 reporting that chronic pancreatitis (CP)-predisposing CPA1 mutations function through the misfolding pathway rather than through loss of CPA1 protein/activity. Herein, we explore an additional insight gleaned from this study beyond those discussed in an accompanying Editorial.2 In the original study reporting the association of CPA1 variants with CP, all unambiguous...