The Influence of Sedentary Behavior on Cancer Risk: Epidemiologic Evidence and Potential Molecular Mechanisms

Sedentary behavior is an emerging risk factor for several cancers. Here, we review the current epidemiologic evidence on sedentary behavior and cancer risk and summarize potential underlying molecular mechanisms. High compared to low sedentary behavior is associated with a 28–44% increased risk of colon cancer, a 8–17% increased risk of breast cancer, and a 28–36% increased risk of endometrial cancer. For other cancer sites, the current evidence...