Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Recombinant mammalian cell line development is a critical step in the current manufacturing process for large-scale production of therapeutic proteins. The current process of cell line development using random transgene integration induces high phenotypic heterogeneity among recombinant clones, thus limiting predictive value, process streamlining, and cost-effectiveness in biopharmaceutical drug discovery and development. Recent advances in...