Quality by design driven development and optimization of teriflunomide loaded nanoliposomes for treatment of rheumatoid arthritis: An in vitro and in vivo assessments

The objective of the present research was to develop teriflunomide-loaded nanoliposomes by thin-film hydration technique for the management of rheumatoid arthritis. Quality by design approach was applied statistically for the optimization of the teriflunomide-nanoliposomalformulation. The vesicle size, polydispersity index, zeta potential and entrapment efficiency of the optimized teriflunomide-nanoliposomal formulation was found to be 128.92 ±...