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Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men

Published on Jun 1, 2019in Diabetes7.199
· DOI :10.2337/db18-1076
Jagadish Vangipurapu11
Estimated H-index: 11
(University of Eastern Finland),
Alena Stančáková49
Estimated H-index: 49
(University of Eastern Finland)
+ 2 AuthorsMauri Laakso139
Estimated H-index: 139
(University of Eastern Finland)
Abstract
Several amino acids have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but none of previous studies has investigated the association of amino acids with insulin secretion in a longitudinal setting. Our study included 5181 participants of the cross-sectional METabolic Syndrome In Men study having metabolomics data on twenty amino acids. A total of 4851 of them had a 4.6-year follow-up visit. Nine amino acids (phenylalanine, tryptophan, tyrosine, alanine, isoleucine, leucine, valine, aspartate and glutamate) were significantly ( P -5 ) associated with decreases in insulin secretion (Disposition index) and the elevation of fasting or 2 hour glucose levels. Five of these amino acids (tyrosine, alanine, isoleucine, aspartate and glutamate) were also found to be significantly associated with an increased risk of incident type 2 diabetes after adjustment for confounding factors. Our study is the first population-based large cohort to report that amino acids are not only associated with insulin resistance but also with decreased insulin secretion.
  • References (25)
  • Citations (3)
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References25
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#1Nicolai J. Wewer Albrechtsen (UCPH: University of Copenhagen)H-Index: 18
#2Anders E Junker (UCPH: University of Copenhagen)H-Index: 5
Last. Tina Vilsbøll (UCPH: University of Copenhagen)H-Index: 40
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Hypersecretion of glucagon (hyperglucagonemia) has been suggested to be linked to type 2 diabetes. Here, we show that levels of amino acids correlate with levels of glucagon. Hyperglucagonemia may ...
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#1Igor Cervenka (KI: Karolinska Institutet)H-Index: 10
#2Leandro Z. Agudelo (KI: Karolinska Institutet)H-Index: 5
Last. Jorge L. Ruas (KI: Karolinska Institutet)H-Index: 28
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BACKGROUND The essential amino acid tryptophan is a substrate for the generation of several bioactive compounds with important physiological roles. Only a small fraction of ingested tryptophan is used in anabolic processes, whereas the large majority is metabolized along the kynurenine pathway of tryptophan degradation. This pathway generates a range of metabolites, collectively known as kynurenines, involved in inflammation, immune response, and excitatory neurotransmission. Kynurenines have be...
106 CitationsSource
#1Mauri Laakso (University of Eastern Finland)H-Index: 139
#2Johanna Kuusisto (University of Eastern Finland)H-Index: 85
Last. Michael Boehnke (UM: University of Michigan)H-Index: 122
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Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, has undergone a rapid technological evolution in the past two decades. These advances have led to the application of metabolomics to defining predictive biomarkers for incident cardiometabolic diseases and, increasingly, as a blueprint for understanding those diseases' pathophysiologic mechanisms. Progress in this area and challenges for the future are reviewed here.
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#1Luca A. Lotta (University of Cambridge)H-Index: 14
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OBJECTIVE Recent studies using untargeted metabolomics approaches have suggested that plasma branched-chain amino acids (BCAAs) are associated with incident diabetes. However, little is known about the role of plasma BCAAs in metabolic abnormalities underlying diabetes and whether these relationships are consistent across ethnic populations at high risk for diabetes. We investigated the associations of BCAAs with insulin sensitivity (S I ), acute insulin response (AIR), and metabolic clearance o...
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Context: Metabolomic profiling of amino acids and acylcarnitines has revealed consistent patterns associated with metabolic disease. Objective: This study used metabolomic profiling to identify analytes associated with insulin sensitivity (SI) and conversion to type 2 diabetes (T2D). Design: A multiethnic cohort from the Insulin Resistance Atherosclerosis Study. Setting: Community-based. Patients: A total of 196 subjects (European American, Hispanic, and African American) were selected to repres...
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Branched-chain amino acid (BCAA) levels are increased in individuals with obesity and are associated with worse metabolic health and future insulin resistance. In this Review, Christopher Lynch and Sean Adams discuss whether and how impaired BCAA metabolism might occur in obesity and how perturbations in BCAA levels reflect the insulin resistant and type 2 diabetes mellitus pathophenotypes.
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#1Jagadish Vangipurapu (University of Eastern Finland)H-Index: 11
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