An eco-friendly sample preparation procedure base on low-density solvent-based air-assisted liquid-liquid microextraction for the simultaneous determination of 21 potential endocrine disruptors in urine samples by liquid chromatography-tandem mass spectrometry

A simple and rapid procedure for simultaneous determination of 21 potential endocrine-disrupting chemicals (EDs) in urine samples by liquid chromatography–tandem mass spectrometry (LC–MS/MS) was developed. The novelty of the present procedure is based on the use of low-density solvent air-assisted liquid-liquid microextraction (LDS–AALLME) as a sample preparation step. The target analytes were 7 bisphenols, 7 parabens, 5 benzophenones, and two...