Calcium Binding to FXIII-A Subunit: Unique Characteristics

Objectives: Calcium ions (Ca2+) play a major role in regulation of coagulation cascade maintaining hemostasis; and are responsible for complete activation of coagulation Factor XIII (FXIII). The catalytic component of FXIII is the protransglutaminase FXIII-A subunit, which gets activated by a combination of thrombin cleavage and binding of calcium ions to its three calcium binding sites (Cab). In this study we follow up on our earlier work where...