Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis

Importance

An American Academy of Orthopaedic Surgeons guideline recommends tramadol for patients with knee osteoarthritis, and an American College of Rheumatology guideline conditionally recommends tramadol as first-line therapy for patients with knee osteoarthritis, along with nonsteroidal anti-inflammatory drugs.

Objective

To examine the association of tramadol prescription with all-cause mortality among patients with...