Vps34/PIK3C3 deletion in thyroid impairs thyroid hormonogenesis and autophagic flux
Abstract
BACKGROUND: The production of thyroid hormones (T3, T4) depends on thyroid organization in follicles, lined by a monolayer of thyrocytes with strict apico-basal polarity. Polarization supports vectorial transport of thyroglobulin for storage into, and recapture from, the colloid. It also allows selective addressing of channels, transporters, pumps and enzymes to their appropriate basolateral (NIS and Na+/K+-ATPase) or apical membrane domain...
Paper Details
Title
Vps34/PIK3C3 deletion in thyroid impairs thyroid hormonogenesis and autophagic flux
Published Date
Mar 16, 2019
Journal
Pages
580142
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History