Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Introduction We investigated relations between amyloid‐β (Aβ) status, apolipoprotein E ( APOE ) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL‐40, and total tau (T‐tau). Methods We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)‐type dementia from the EMIF‐AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL,...