Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy
Abstract
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder, characterised by myocyte remodeling, disorganisation of sarcomeric proteins, impaired energy metabolism and altered cardiac contractility. Gene mutations encoding cardiac contractile proteins account for 60% of HCM aetiology. Current drug therapy including L-type calcium channel antagonists, are used to manage symptoms in patients with overt HCM, but no treatment exists that can...
Paper Details
Title
Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy
Published Date
Apr 1, 2019
Volume
665
Pages
166 - 174
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