Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction

Cellular signaling cascades adapt to changing environments through multiple feedback mechanisms. Pre-activation of the IFNα signal-transduction pathway can cause a desensitized state in which the system is not responding to further treatment which constitutes a serious therapeutic problem. Even though the involvement of USP18 as one of the key negative regulators has been reported, the underlying mechanisms as well as the role of further...